ARG67163
anti-CSN5A + CSN5B antibody
anti-CSN5A + CSN5B antibody for Western blot and Arabidopsis
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CSN5A and CSN5B |
|---|---|
| Tested Reactivity | Arabi |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CSN5A + CSN5B |
| Antigen Species | Plant |
| Immunogen | Synthetic peptide corresponding to center region of arabidopsis thaliana CSN5A/B protein. |
| Conjugation | Un-conjugated |
| Alternate Names | AJH1; CSN5B; COP9 signalosome complex subunit 5a; Signalosome subunit 5a; Jun activation domain-binding homolog 1; AJH2; CSN5A; COP9 signalosome complex subunit 5b; Signalosome subunit 5b; Jun activation domain-binding homolog 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | 40 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 30% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CSN5A; CSN5B |
|---|---|
| Gene Full Name | COP9 signalosome 5A + COP9 signalosome 5B |
| Background | CSN5A: AJH1 encodes a protein similar to JAB1, a specific mammalian coactivator of AP-1 transcription. Encodes a subunit of the COP9 complex that is involved in protein deneddylation. Plants with mutations in CSN5A and CSN5B have a de-etiolated phenotype. CSN5B: Encodes a subunit of the COP9 complex, similar to JAB1, a specific mammalian coactivator of AP-1 transcription. Involved in protein deneddylation. Double mutants with CSN5A are constitutively photomorphogenic (de-etiolated) and have abnormal auxin responses. |
| Function | The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. [UniProt] The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. [UniProt] Involved in CSN's deneddylation/derubylation activity. [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus. [UniProt] |
| Calculated MW | 39;40 kDa |
Images (1) Click the Picture to Zoom In
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ARG67163 anti-CSN5A + CSN5B antibody WB image
Western blot: Arabidopsis thaliana stained with ARG67163 anti-CSN5A + CSN5B antibody.
