ARG41620
anti-CDKN1C / p57 Kip2 antibody
anti-CDKN1C / p57 Kip2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CDKN1C / p57 Kip2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CDKN1C / p57 Kip2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human CDKN1C / p57 Kip2. |
| Conjugation | Un-conjugated |
| Alternate Names | Cyclin-dependent kinase inhibitor p57; BWS; WBS; BWCR; KIP2; Cyclin-dependent kinase inhibitor 1C; p57; p57Kip2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Positive Control | HeLa | ||||||||||
| Observed Size | ~ 50 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P49918 Human Cyclin-dependent kinase inhibitor 1C Swiss-port # P49919 Mouse Cyclin-dependent kinase inhibitor 1C |
|---|---|
| Gene Symbol | CDKN1C |
| Gene Full Name | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| Background | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| Function | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 32 kDa |
Images (3) Click the Picture to Zoom In
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ARG41620 anti-CDKN1C / p57 Kip2 antibody ICC/IF image
Immunofluorescence: HeLa cells treated with dexamethasone. Cells were stained with ARG41620 anti-CDKN1C / p57 Kip2 antibody.
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ARG41620 anti-CDKN1C / p57 Kip2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat kidney tissue stained with ARG41620 anti-CDKN1C / p57 Kip2 antibody.
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ARG41620 anti-CDKN1C / p57 Kip2 antibody WB image
Western blot: HeLa cell lysate stained with ARG41620 anti-CDKN1C / p57 Kip2 antibody.
