ARG62918

anti-CD7 antibody [MEM-186]

anti-CD7 antibody [MEM-186] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human

Immune System antibody

Overview

Product Description Mouse Monoclonal antibody [MEM-186] recognizes CD7
Tested Reactivity Hu
Tested Application FACS, IHC-P, IP, WB
Specificity The clone MEM-186 reacts with CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.
HLDA VI; WS Code T 6T-015
Host Mouse
Clonality Monoclonal
Clone MEM-186
Isotype IgG1
Target Name CD7
Antigen Species Human
Immunogen Human acute myelogenous leukaemia cell line KG-1.
Conjugation Un-conjugated
Alternate Names TP41; Tp40; T-cell antigen CD7; CD antigen CD7; T-cell leukemia antigen; LEU-9; T-cell surface antigen Leu-9; GP40

Application Instructions

Application Suggestion
Tested Application Dilution
FACS2 µg/ml
IHC-P5 µg/ml
IPAssay-dependent
WBAssay-dependent
Application Note WB: Under non-reducing condition.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control IHC-P: Spleen

Properties

Form Liquid
Purification Purified by protein A
Purity > 95% (by SDS-PAGE)
Buffer PBS (pH 7.4) and 15 mM Sodium azide
Preservative 15 mM Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 924 Human CD7

Swiss-port # P09564 Human T-cell antigen CD7

Gene Symbol CD7
Gene Full Name CD7 molecule
Background CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.
Function Not yet known. [UniProt]
Highlight Related products:
CD7 antibodies; CD7 ELISA Kits; CD7 Duos / Panels; Anti-Mouse IgG secondary antibodies;
Related news:
Lymphoma
Research Area Immune System antibody
Calculated MW 25 kDa