ARG42421
anti-CD267 / TACI antibody [1A1] (APC)
anti-CD267 / TACI antibody [1A1] (APC) for Flow cytometry and Human
Overview
| Product Description | APC-conjugated Rat Monoclonal antibody [1A1] recognizes CD267 / TACI |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 1A1 |
| Isotype | IgG |
| Target Name | CD267 / TACI |
| Antigen Species | Human |
| Immunogen | CD267-transfected RBL cells. |
| Conjugation | APC |
| Alternate Names | Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor; TNFRSF14B; IGAD2; CD267; RYZN; TACI; CD antigen CD267; CVID; CVID2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O14836 Human Tumor necrosis factor receptor superfamily member 13B |
|---|---|
| Gene Symbol | TNFRSF13B |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 13B |
| Background | The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] |
| Function | Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. [UniProt] |
| Cellular Localization | Membrane; Single-pass type III membrane protein. [UniProt] |
| Calculated MW | 32 kDa |
Images (3) Click the Picture to Zoom In
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ARG42421 anti-CD267 / TACI antibody [1A1] (APC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG42421 anti-CD267 / TACI antibody [1A1] (APC) at 10 µl / 100 µl of peripheral whole blood.
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ARG42421 anti-CD267 / TACI antibody [1A1] (APC) FACS image
Flow Cytometry: Human lymphocytes stained with ARG42421 anti-CD267 / TACI antibody [1A1] (APC) at 10 µl / 100 µl of peripheral whole blood and co-stained with ARG53783 anti-CD19 antibody [LT19] (PE) at 20 µl / 100 µl of peripheral whole blood.
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ARG42421 anti-CD267 / TACI antibody [1A1] (APC) FACS image
Flow Cytometry: Separation of Human CD267 positive CD19 positive lymphocytes (red-filled) from Human CD267 negative CD19 negative lymphocytes (black-dashed). Human peripheral whole blood stained with ARG42421 anti-CD267 / TACI antibody [1A1] (APC) at 10 µl / 100 µl of peripheral whole blood.
