ARG42320
anti-CD134 / OX40 antibody [Ber-ACT35] (APC)
anti-CD134 / OX40 antibody [Ber-ACT35] (APC) for Flow cytometry and Human,Primates
Overview
| Product Description | APC-conjugated Mouse Monoclonal antibody [Ber-ACT35] recognizes CD134 / OX40 |
|---|---|
| Tested Reactivity | Hu, NHuPrm |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Ber-ACT35 |
| Isotype | IgG1, kappa |
| Target Name | CD134 / OX40 |
| Antigen Species | Human |
| Immunogen | HTLV 1-transformed HUT-102 cells. |
| Conjugation | APC |
| Alternate Names | CD134; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; OX40L receptor; Tumor necrosis factor receptor superfamily member 4; OX40; CD antigen CD134; IMD16; ACT35 antigen; ACT35 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P43489 Human Tumor necrosis factor receptor superfamily member 4 |
|---|---|
| Gene Symbol | TNFRSF4 |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 4 |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
| Function | Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 29 kDa |
Images (3) Click the Picture to Zoom In
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ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) FACS image
Flow Cytometry: Human PHA stimulated peripheral blood mononuclear cells stained with ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
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ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) FACS image
Flow Cytometry: Human PHA stimulated peripheral blood mononuclear cells stained with ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension and ARG53801 anti-CD25 antibody [MEM-181] (PE) at 20 µl / 100 µl of peripheral whole blood.
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ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) FACS image
Flow Cytometry: Separation of Human CD134 positive CD25 positive cells (red-filled) from CD134 negative CD25 negative cells (black-dashed). Human PHA stimulated peripheral blood mononuclear cells stained with ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
