ARG58328
anti-CAPZA2 antibody
anti-CAPZA2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CAPZA2 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CAPZA2 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-286 of Human CAPZA2 (NP_006127.1). |
| Conjugation | Un-conjugated |
| Alternate Names | F-actin-capping protein subunit alpha-2; CapZ alpha-2; CAPZ; CAPPA2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | THP-1 | ||||||
| Observed Size | 38 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P47754 Mouse F-actin-capping protein subunit alpha-2 Swiss-port # P47755 Human F-actin-capping protein subunit alpha-2 |
|---|---|
| Gene Symbol | CAPZA2 |
| Gene Full Name | capping protein (actin filament) muscle Z-line, alpha 2 |
| Background | The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008] |
| Function | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. [UniProt] |
| Calculated MW | 33 kDa |
Images (1) Click the Picture to Zoom In
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ARG58328 anti-CAPZA2 antibody WB image
Western blot: 25 µg of THP-1 cell lysate stained with ARG58328 anti-CAPZA2 antibody at 1:1000 dilution.
Specific References
A structure-derived mechanism reveals how capping protein promotes nucleation in branched actin networks.
WB / Mouse
