ARG10776
anti-Bestrophin antibody
anti-Bestrophin antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,Immunohistochemistry,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Bestrophin |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | Confocal, Dot, ELISA, ICC/IF, IHC, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Bestrophin |
| Antigen Species | Human |
| Immunogen | Synthetic peptide from Human Bestrophin. |
| Conjugation | Un-conjugated |
| Alternate Names | Vitelliform macular dystrophy protein 2; RP50; BMD; TU15B; VMD2; Bestrophin-1; ARB; BEST |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BEST1 |
| Gene Full Name | bestrophin 1 |
| Background | This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008] |
| Function | Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. [UniProt] |
| Highlight | Related products: Bestrophin antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Gene therapy for retinitis pigmentosa (RP) |
| Calculated MW | 68 kDa |
| PTM | Phosphorylated by PP2A. |
Images (2) Click the Picture to Zoom In
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ARG10776 anti-Bestrophin antibody ICC/IF image
Immunofluorescence: Basolateral cells stained with ARG10776 anti-Bestrophin antibody (green) at 1:100 dilution. DAPI (blue) for nuclear staining.
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ARG10776 anti-Bestrophin antibody WB image
Western blot: Recombinant Bestrophin protein stained with ARG10776 anti-Bestrophin antibody at 1:500 dilution.
