ARG83146
Mouse IGFBP3 ELISA Kit
Mouse IGFBP3 ELISA Kit for ELISA and Mouse
Cell Biology and Cellular Response kit; Cell Death kit; Metabolism kit; Signaling Transduction kit
Overview
| Product Description | ARG83146 Mouse IGFBP3 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse IGFBP3 in Serum, Cell culture supernatants. |
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| Tested Reactivity | Ms |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | IGFBP3 |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 15 pg/ml |
| Detection Range | 156 pg/ml - 10,000 pg/ml |
| Sample Type | Serum and Cell culture supernatants. |
| Precision | Intra-Assay CV: 3.34% Inter-Assay CV: 3.1% |
| Alternate Names | IBP3; BP-53; IGF-binding protein 3; IGFBP-3 |
Application Instructions
| Assay Time | ~ 5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P47878 Mouse Insulin-like growth factor-binding protein 3 |
|---|---|
| Gene Symbol | IGFBP3 |
| Gene Full Name | Insulin Like Growth Factor Binding Protein 3 |
| Background | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. [UniProt] |
| Research Area | Cell Biology and Cellular Response kit; Cell Death kit; Metabolism kit; Signaling Transduction kit |
| PTM | Phosphorylated by FAM20C in the extracellular medium. |
Images (1) Click the Picture to Zoom In
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ARG83146 Mouse IGFBP3 ELISA Kit standard curve image
ARG83146 Mouse IGFBP3 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83146 Mouse IGFBP3 ELISA Kit User manual |
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