ARG70431
Human CXCL13 / BCA1 recombinant protein (Active) (His-tagged, N-ter)
Human CXCL13 / BCA1 recombinant protein (Active) (His-tagged, N-ter) for SDS-PAGE
Overview
| Product Description | E. coli expressed, His-tagged (N-ter) Active Human CXCL13 / BCA1 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CXCL13 / BCA1 |
| Species | Human |
| A.A. Sequence | Val23 - Arg94 |
| Expression System | E. coli |
| Protein Full Name | C-X-C motif chemokine 13 |
| Activity | Active |
| Activity Note | Determined by its ability to chemoattract BaF3 cells transfected with human CXCR5. The ED50 for this effect is <20 ng/mL. |
| Alternate Names | CXCL13; C-X-C Motif Chemokine Ligand 13; BCA-1; BLC; ANGIE2; SCYB13; BLR1L; ANGIE; Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant); B Cell-Attracting Chemokine; B Lymphocyte Chemoattractant |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is <0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | >98% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not <200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CXCL13 |
|---|---|
| Gene Full Name | C-X-C Motif Chemokine Ligand 13 |
| Background | B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. |
| Function | Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. |
| Cellular Localization | Secreted |
| PTM | Disulfide bond |
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ARG70431 Human CXCL13 / BCA1 recombinant protein (Active) (His-tagged, N-ter)SDS-PAGE image
SDS-PAGE analysis of ARG70431 Human CXCL13 / BCA1 recombinant protein (Active) (His-tagged, N-ter)
